2H-Imidazo[4,5-b]pyridin-2-one, 1,3-dihydro-5-methyl-6-(4-pyridinyl)- - Names and Identifiers
2H-Imidazo[4,5-b]pyridin-2-one, 1,3-dihydro-5-methyl-6-(4-pyridinyl)- - Physico-chemical Properties
Molecular Formula | C12H10N4O
|
Molar Mass | 226.23 |
Density | 1.45±0.1 g/cm3(Predicted) |
pKa | 7.36±0.60(Predicted) |
Storage Condition | -20℃ |
In vitro study | Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with K i values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes. |
In vivo study | After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h. |
2H-Imidazo[4,5-b]pyridin-2-one, 1,3-dihydro-5-methyl-6-(4-pyridinyl)- - Introduction
Win-62005 is a chemical substance whose chemical name is N-(4-propenylphenyl)-2-(2-nitrophenyl) aniline. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Win-62005 is white crystalline powder.
-Solubility: It is soluble in some organic solvents, such as chloroform, dimethylformamide, etc.
-Melting point: Its melting point is about 82-86 degrees Celsius.
-chemical structure: molecular formula for C19H16N2O2, relative molecular mass of 308.35.
Use:
- Win-62005 is commonly used in organic synthesis of nitrogen reaction and coupling reaction.
-It can also be used as a chemical reagent and intermediate for the preparation of other compounds.
-Because of its strong blue fluorescence, it plays an important role in fluorescence microscopy and fluorescence spectroscopy.
Preparation Method:
The preparation method of-Win-62005 can be achieved through a series of organic synthesis reactions. The specific preparation method varies with the purpose and conditions of the study, and generally includes the substitution reaction and coupling reaction of aniline compounds.
Safety Information:
- Win-62005 No detailed toxicity data reported. However, as an organic compound, it may be harmful to human health.
-Standard safety measures should be taken during handling and storage, such as wearing appropriate protective gloves and eye protection equipment.
-In use should be careful to avoid direct contact with the skin, inhalation or ingestion. In case of carelessness, wash the relevant parts with plenty of water immediately and seek medical help in time.
Last Update:2024-04-10 22:29:15